Nanostructured materials offer a very specific surface area, typically in the range of 1000-4000 m2/gram. This enfavours a very high adsorption capacity. Selectivity for capturing only the toxins from the blood and not the valuable components is achieved by fine-tuning the surface chemistry as well as the nanoporosity of the sorbent material. Our sorbent system is therefore both efficient as well as selective for toxins thanks to the use of nanostructured materials. For the miniature artificial kidney, sorbents are used in combination with electrocatalytic oxidation. This allows the removal of all important toxins.
Nanoporous polymer matrix
- capturing small electrolytes such as potassium and phosphate
- sorption of middle molecules such as creatinine, β2m, urate
- capturing protein bound toxins such as PAH, p-cresol, CMPF, indoxyl sulphate
- decomposing and gasifying urea and other organic toxins into N2, CO2 and H2
Once the sorbents are saturated with toxins, the sorption unit is flushed with a regeneration fluid. Hereby toxins are removed from the unit and the sorption unit can be re-used over and over.
Prototype being tested in animal trial